Randomization Schemas

SCiAN assists Sponsors with developing randomization schemas that minimize the variability of the parameter of interest and avoid confounding from other factors.  We are experienced in the following types of randomization:

  • Simple: randomize subjects to one of two treatment groups
  • Block: randomize subjects into treatment groups in blocks to ensure balance in sample size across groups over time. The block size is a multiple of the number of treatment groups.
  • Stratified: randomize subjects to achieve balance among the treatment groups in terms of covariates, e.g. subject’s baseline characterstics.
  • Dynamic: also known as adaptive randomization. An example is the minimization method in which subjects are randomized to a particular treatment group based on specific covariates and previous assignments of subjects.