Specifications are created based on three ADaM data structures: the ADaM Subject-Level structure (ADSL), Basic Data Structure (BDS) and Occurrence Data Structure (OODS).  All ADaM specifications are developed to follow the fundamental principles described in the ADaM model document with traceability at the metadata level and the datapoint level (if possible). 

The key reference documents for ADaM datasets are the Statistical Analysis Plan (SAP) and the Tables, Listings & Figure (TLFs) shells.

The source data for the ADaM datasets are the SDTM datasets or the raw (native) study database.